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Now, a saliva-based oral cancer detection test
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Now, a saliva-based oral cancer detection test
Washington: Scientists have now discovered a saliva-based oral cancer detection test, thus paving the way for early detection of the disease that kills approximately one person every hour.
Oral cancer can spread quickly. The majority of oral cancers are diagnosed in late stages, which accounts for the high death rates. Only half of those diagnosed with the disease will survive more than five years.
However, if the cancer is detected early, there is an 80 to 90 percent chance for survival. It is therefore extremely important to detect oral cancer as early as possible, when it can be treated more successfully, thus enhancing the rate of survival.
Currently, the early detection of oral cancer depends on a thorough oral cancer examination, usually by a dentist or other qualified health care provider, for possible signs and symptoms of this disease.
Scientists are working on technologies and biomarkers for the early detection of oral cancer. Saliva, an easy-to-obtain and non-invasive body fluid, has recently been shown to harbor highly informative biomarkers for oral cancer detection.
Scientists in Dr. David Wong’s laboratory at the School of Dentistry at UCLA have discovered that seven RNAs, molecules that carry information in cells, when found in saliva are very useful for oral cancer detection.
The saliva oral cancer RNA signature has been tested in over 300 saliva samples from oral cancer patients and healthy people, and the signature is always present in higher levels in the saliva of oral cancer patients than in saliva from healthy people, with an overall accuracy rate of about 85 percent.
Wong’s research team is reporting for the first time that they have developed a standardized “Saliva RNA Test for Oral Cancer” ready for clinical usage. The “Saliva RNA Test” has been tested in 100 oral cancer and healthy people, and it has been confirmed that four saliva oral cancer RNA biomarkers are highly accurate in detecting oral cancer, at around 82 percent.
This is the first standardized saliva-based test for clinical oral cancer detection and will have enormous clinical value in reducing the mortality and morbidity for oral cancer patients, as well as improving their quality of life.
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